Leukocyte interactions with surface modified biomaterials on in vitro flow conditions

نویسندگان
چکیده

منابع مشابه

Biomaterials: Protein–Surface Interactions

The study of protein–surface interactions represents one of the most important topics in the field of biomaterials, and as such, it has been a focus of intensive study for several decades. The reason for the great interest in this topic is the realization that protein– surface interactions are fundamentally responsible for the biocompatibility of medical devices, or the lack thereof. When a sol...

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E-selectin polymorphism associated with myocardial infarction causes enhanced leukocyte-endothelial interactions under flow conditions.

OBJECTIVE Polymorphisms found in genes encoding adhesion molecules have been reported to be associated with atherosclerosis. We investigated the Ser128Arg polymorphism in the E-selectin gene in Japanese patients with myocardial infarction and its functional significance. METHODS AND RESULTS Results from 135 patients with myocardial infarction and 327 control subjects revealed that the frequen...

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The effect of starch-based biomaterials on leukocyte adhesion and activation in vitro.

Leukocyte adhesion to biomaterials has long been recognised as a key element to determine their inflammatory potential. Results regarding leukocyte adhesion and activation are contradictory in some aspects of the material's effect in determining these events. It is clear that together with the wettability or hydrophilicity/hydrophobicity, the roughness of a substrate has a major effect on leuko...

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Leukocyte-leukocyte interactions mediated by platelet microparticles under flow.

Platelet microparticles (PMPs) are released from activated platelets and express functional adhesion receptors, including P-selectin, on their surface. PMP concentrations are elevated in many disorders, and their role in accelerating coagulation has been studied. However, their role in leukocyte aggregation has not been defined. We hypothesized that P-selectin-expressing PMPs bridge leukocytes ...

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Assessing Leukocyte-endothelial Interactions Under Flow Conditions in an Ex Vivo Autoperfused Microflow Chamber Assay

Leukocyte-endothelial interactions are early and critical events in acute and chronic inflammation and can, when dysregulated, mediate tissue injury leading to permanent pathological damage. Existing conventional assays allow the analysis of leukocyte adhesion molecules only after the extraction of leukocytes from the blood. This requires the blood to undergo several steps before peripheral blo...

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ژورنال

عنوان ژورنال: Critical Care

سال: 1999

ISSN: 1364-8535

DOI: 10.1186/cc328